Searchable abstracts of presentations at key conferences in endocrinology

ea0026oc3.4 | Bone/Reproduction | ECE2011

Low doses of bisphenol A promote human seminoma cell proliferation in vitro by activating PKA and PKG via the non classical membrane G protein-coupled estrogen receptor (GPER)

Fenichel P , Vega A , Bouskine A , Brucker-Davis Fr , Benahmed M , Chevalier N

Fetal exposure to environmental estrogens may contribute to hypofertility and/or to testicular germ cell cancer. However, many of these endocrine disruptors have only a weak affinity for the classical ERs and other mechanisms have been suggested. Bisphenol A, a chemical poluttant, used as monomer to manufacture polycarbonate plastic, released from lining canned food or beverages or from dental sealants, was able to promote human testicular seminoma cell (JKT-1) proliferation <...